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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
Affiliation:1. Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Milano, Italy;2. Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy;3. Institute for Systems Analysis and Computer Science “Antonio Ruberti,” National Research Council, Rome, Italy;4. Department of Paediatric Haematology, Oncology and Stem Cell Transplantation, University Hospital of Würzburg, Würzburg, Germany;5. Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, San Raffaele Vita-Salute University, Milano, Italy;6. Interdisciplinary Center for Clinical Research (IZKF), Experimental Stem Cell Transplantation Laboratory, Würzburg University Hospital, Würzburg, Germany;7. Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria;8. Broad Institute of MIT and Harvard, Cambridge, MA, USA;9. Fondazione Pisana per la Scienza, ONLUS, San Giuliano Terme, Italy;10. Institute of Life Sciences, Sant’ Anna School of Advanced Studies, Pisa, Italy;11. Immunology Research Area, Innate Lymphoid Cells Unit, Bambino Gesù Children''s Hospital IRCCS, Rome, Italy;12. Clinical Research Division and Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;13. Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
Abstract:
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  • Keywords:CD8 T cells  metabolic fitness  lipid metabolism  adoptive T cell therapy  linoleic acid
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