A Model Combining Testosterone,Androstenedione and Free Testosterone Index Improved the Diagnostic Efficiency of Polycystic Ovary Syndrome |
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| Affiliation: | 1. Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;2. School of Medicine, Tongji University, Shanghai, China;1. Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland;2. Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida;3. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, Maryland;4. Section on Hospital Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina;5. Center for Prevention of Cardiovascular Disease, Section on Cardiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina;1. Precision Care Clinic Corp, Saint Cloud, Florida;2. Department of Global Health and Population, Harvard TH Chan School of Public Health, Harvard University, Boston, Massachusetts;3. Foundation for Clinic, Public Health, and Epidemiology Research of Venezuela (FISPEVEN INC), Caracas, Venezuela;4. Division of Endocrinology, Diabetes and Bone Disease, The Marie-Josée and Henry R. Kravis Center for Cardiovascular Health at Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York;5. International Clinical Research Center, St Anne’s University Hospital (ICRC-FNUSA), Brno, Czech Republic;6. Public Health Research Unit, Department of Social and Preventive Medicine, School of Medicine, Universidad Centro-Occidental “Lisandro Alvarado”, Barquisimeto, Venezuela;7. Department of Physiology and Biophysics, School of Medicine, Georgetown University, Washington, District of Columbia;8. Nutrition and Diabetes Unit, Clínica Red Salud Vitacura, Santiago, Chile;9. Nutrition and Diabetes Service, Santiago Military Hospital, Santiago, Chile;10. Universidad de Los Andes, Santiago, Chile;1. Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia;2. Division of Endocrinology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia;3. Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia;4. Division of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia;5. Clinical Resource Hub Veterans Integrated Service Network VISN 7, Atlanta, Georgia;1. Department of Medicine, Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia;2. Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, Melbourne, Victoria, Australia;3. Falls, Balance and Injury Research Centre, Neuroscience Research Australia (NeuRA), Randwick, New South Wales, Australia;4. Faculty of Medicine and Health, School of Population Health, University of New South Wales, Sydney, New South Wales, Australia;5. Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada;6. Dr. Joseph Kaufmann Chair in Geriatric Medicine, McGill University, Montreal, Quebec, Canada;1. Diabetes Technology Society, Burlingame, California;2. Department of Internal Medicine, Campania University “Luigi Vanvitelli”, Naples, Italy;3. NefroCenter Research Network, Torre del Greco, Naples, Italy;4. Science Consulting in Diabetes, Kaarst, Germany;5. Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia;6. Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University, Baltimore, Maryland;7. Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia;8. Jefferson Artificial Pancreas Center, Thomas Jefferson University, Philadelphia, Pennsylvania;9. Division of Endocrinology, Diabetes and Metabolism, Weill Cornell Medicine, New York, New York;10. Diabetes Research Institute, Mills-Peninsula Medical Center, San Mateo, California |
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| Abstract: | ObjectiveHyperandrogenism is frequently observed in patients with polycystic ovary (PCO). The purpose of this study was to develop an easy-to-use tool for predicting polycystic ovary syndrome (PCOS) and to evaluate and compare the value of androstenedione (Andro) and other hormone indicators in the diagnosis of patients with hyperandrogenic PCOS.MethodsThis study included 139 women diagnosed with hyperandrogenic PCOS according to the Rotterdam criteria and 74 healthy control women from Shanghai Tenth People's Hospital. The serum hormone levels of the patients and controls were measured using a chemiluminescence immunoassay and incorporated for further analysis.ResultsTotal testosterone (TT), Andro, dehydroepiandrosterone sulfate (DHEAS), and free androgen index (FAI) were significantly higher in the PCOS group than the control group. Further, Andro, follicle-stimulating hormone (FSH), luteinizing hormone (LH), TT, FAI, and LH/FSH in the hyperandrostenedione group were higher than the normal Andro group. The Youden index was the highest for Andro (0.65), with 81.82% sensitivity and 83.16% specificity. Correlation analysis showed that FSH, LH, TT, FAI, insulin sensitivity index, and LH/FSH were positively correlated with Andro, while fasting blood glucose and 2-hour postprandial blood glucose were negatively correlated with Andro.ConclusionsThe model using Andro, TT, and FAI may help to identifying women with undiagnosed PCOS. Serum Andro is a meaningful biomarker for hyperandrogenism in PCOS patients and may further aid disease diagnosis. |
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| Keywords: | PCOS hyperandrogenism androstenedione steroid hormones diagnostic 2hINS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" 2-hour postprandial insulin 2h PG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" 2-hour postprandial blood glucose Andro" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" androstenedione DHEAS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" dehydroepiandrosterone sulfate FAI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" free androgen index FBG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" fasting blood glucose FINS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" fasting insulin HDLC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" high density lipoprotein HOMA-IR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" insulin resistance index ISI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" insulin sensitivity index LDLC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" low density lipoprotein LH/FSH" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" luteinizing hormone/follicle-stimulating hormone MS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" mass spectrometry PCOS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" polycystic ovarian syndrome SHBG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" sex hormone binding globulin TC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" total cholesterol TG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" triglyceride TT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210" }," $$" :[{" #name" :" text" ," _" :" total testosterone |
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