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Adipose tissue at single-cell resolution
Affiliation:1. Center for Functional Genomics and Tissue Plasticity, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark;2. Department of Internal Medicine, Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, TX, USA;1. Department of Cardiology, National University Heart Centre, National University Health System, Singapore, Singapore;2. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;3. Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore;4. National University Centre for Organ Transplantation, National University Health System, Singapore, Singapore;5. Division of General Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore;6. Division of Endocrinology, Department of Medicine, National University Hospital, Singapore, Singapore;7. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;8. Cardiovascular Research Institute, National University Heart Centre, National University Health System, Singapore, Singapore;9. Nanomedicine Translational Research Programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;10. Department of Endocrinology ASO/Easo COM, King''s College Hospital NHS Foundation Trust, Denmark Hill, London, UK;11. Obesity, Type 2 Diabetes and Immunometabolism Research Group, Department of Diabetes, Faculty of Cardiovascular Medicine & Sciences, School of Life Course Sciences, King’s College London, London, UK;12. Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA;13. National Heart Centre Singapore, Singapore, Singapore;14. Duke-NUS Medical School, Singapore, Singapore;15. Northern Clinical School, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW, Australia;16. Department of Cardiology, Royal North Shore Hospital, Sydney, NSW, Australia;17. UW Medicine Diabetes Institute, VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA;18. Houston Research Institute, Houston, TX, USA;19. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China;20. Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China;21. Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong, China;22. Section of Endocrinology, Boston VA Healthcare System, Boston, MA, USA;23. Faculty of Medicine, Harvard University, Boston, MA, USA;1. Department of Neurobiology and Medicine, Harvard Medical School, Boston, MA, USA;1. Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA 02132, USA;2. Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA;3. Department of Pediatrics, University of California San Diego, La Jolla, CA 92161, USA;4. Simulation and Modeling Sciences, Pfizer Worldwide Research, Development and Medical, Cambridge, MA 02139, USA;5. Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA;6. Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;7. Genomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA 02132, USA;8. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA;9. Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA;10. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK;11. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA;12. Tailored Therapeutics-Diabetes, Eli Lilly and Company, Lilly Corporate Center DC 0545, Indianapolis, IN 46285, USA;13. Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA 02139, USA;14. Team Early Projects Type 1 Diabetes, Therapeutic Area Diabetes and Cardiovascular Medicine, Research & Development, Sanofi, Industriepark Höchst-H831, Frankfurt am Main 65926, Germany;15. Merck Research Laboratories, Boston, MA 02115, USA;16. Integrative Biology, Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA 02139, USA;17. Foundation for the National Institutes of Health, North Bethesda, MD 20852, USA;18. Janssen Pharmaceuticals Inc., Titusville, NJ 08560, USA;19. CardioMetabolism & Respiratory Medicine, Boehringer Ingelheim International GmbH, 55216 Ingelheim/Rhein, Germany;20. Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA;21. Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 9DU, UK;22. Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, Oxford OX3 7BN, UK;1. Department of Endocrinology and Nutrition, Research Unit, Institut d’Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari de Tarragona Joan XXIII, Tarragona 43005, Spain;2. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid 28029, Spain;3. Department of Medicine and Surgery, Universitat Rovira i Virgili (URV), Reus 43201, Spain;4. Institut d’Oncologia de la Catalunya Sud, Hospital Universitari Sant Joan de Reus, IISPV, Reus 43204, Spain;5. Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid (CSIC/UAM), Madrid 28029, Spain;6. Departament de Ciències Fisiològiques, Universitat de Barcelona, IDIBELL, Hospitalet de Llobregat, Barcelona 08907, Spain;7. Department of Pathology, Oncological Pathology and Bioinformatics Research Group, Hospital de Tortosa Verge de la Cinta, IISPV, Tortosa 43500, Spain;8. General and Digestive Surgery Service, Hospital Sant Pau i Santa Tecla, Institut d''Investigació Sanitària Pere Virgili, Tarragona 43003, Spain;9. Institut d’Investigacions Biomèdiques (IIB) Sant Pau, Barcelona 08041, Spain;10. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona 08193, Spain;11. Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), Salt 17190, Spain;12. CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03/010), Instituto de Salud Carlos III, Madrid 28029, Spain;13. Department of Medical Sciences, School of Medicine, University of Girona, Girona 17004, Spain;14. Department of Endocrinology and Nutrition, Hospital Universitari Bellvitge – IDIBELL, Hospitalet de Llobregat, Barcelona 08907, Spain;1. Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA;2. Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA;3. Live Cell Imaging Core Facility, UT Southwestern Medical Center, Dallas, TX 75390, USA;4. Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA;5. Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA;6. Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA;7. Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA;1. Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany;2. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany;3. Research Unit NeuroBiology of Diabetes, Helmholtz Zentrum München, 85764 Neuherberg, Germany;4. Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany;5. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Medical Drive 8, Singapore 117597, Singapore;6. Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia;7. Institute of Developmental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany;8. Developmental Genetics, TUM School of Life Sciences, Technische Universität München, Freising-Weihenstephan, Germany;9. Deutsches Institut für Neurodegenerative Erkrankungen (DZNE) Site Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany;10. Munich Cluster for Systems Neurology (SyNergy), Adolf-Butenandt-Institut, LudwigMaximilians Universität München, Feodor-Lynen-Str. 17, 81377 Munich, Germany;11. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA;12. Division of Neurobiology of Diabetes, TUM School of Medicine, Technical University of Munich, 80333 Munich, Germany;13. Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany;14. Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, 80336 Munich, Germany
Abstract:
Keywords:single-cell sequencing  single-nuclei sequencing  cellular heterogeneity  adipose tissue plasticity  adipocytes  macrophages  preadipocytes  fibro-adipogenic progenitors  adipogenesis  inflammation
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