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A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies |
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| Authors: | Shilei Ding Maxime Veillette Mathieu Coutu Jérémie Prévost Louise Scharf Pamela J. Bjorkman Guido Ferrari James E. Robinson Christina Stürzel Beatrice H. Hahn Daniel Sauter Frank Kirchhoff George K. Lewis Marzena Pazgier Andrés Finzi |
| Abstract: | Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals. |
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