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Metals and inorganic molecules in regulating protein and nucleic acid phase separation |
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| Affiliation: | 1. Department of Biochemistry, University of Colorado, Boulder, 3415 Colorado Ave, CO, 80303, Boulder, United States;2. BioFrontiers Institute, University of Colorado, Boulder, 3415 Colorado Ave, CO, 80303, Boulder, United States;1. Department of Chemistry, The University of Chicago, 929 E 57th St, Chicago, IL 60637, USA;2. Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, 5758, S Maryland Ave, Chicago, IL 60637, USA;1. German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075 Gӧttingen, Germany;2. Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Gӧttingen, Germany |
| Abstract: | The realization that liquid–liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells has motivated efforts to modulate the condensation process of biomolecules. Increasing evidence shows that metals and inorganic molecules abundantly distributed in cells play important roles in the regulation of biomolecular condensation. Herein, we briefly reviewed the background of biomacromolecular phase separation and summarized the recent research progress on the roles of metals and inorganic molecules in regulating protein and nucleic acid phase separation in vitro and in cells. |
| Keywords: | Phase separation Metal cations Inorganic molecules Proteins Nucleic acids |
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