Human Herpesvirus 6A U14 Is Important for Virus Maturation |
| |
| Authors: | Junko Mori Huamin Tang Akiko Kawabata Masato Koike Yasuko Mori |
| |
| Institution: | aDivision of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Japan;bDepartment of Immunology, Nanjing Medical University, Nanjing, China;cDepartments of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan |
| |
| Abstract: | Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation. |
| |
| Keywords: | |
|
|
