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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state,and its deletion improves checkpoint blockade
Affiliation:1. Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;2. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Department of Pathology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;4. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA;5. Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;6. Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;7. Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Abstract:
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  • Keywords:Tribbles  LCMV clone 13  immnotherapy  CD8 T cell exhaustion  PD-L1  Immune checkpoint blockade  CP: Immunology
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