Structure of an HIV-2 gp120 in Complex with CD4 |
| |
| Authors: | Yunji W. Davenport Anthony P. West Jr. Pamela J. Bjorkman |
| |
| Affiliation: | Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA |
| |
| Abstract: | HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-Å structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence. |
| |
| Keywords: | |
|
|
