Dietary Supplementation with Organoselenium Accelerates Recovery of Bladder Expression,but Does Not Improve Locomotor Function,following Spinal Cord Injury |
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| Authors: | Carolyn A. Meyer Ranjana Singh Mackenzie T. Jones Chen-Guang Yu Ronan F. Power James W. Geddes |
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| Affiliation: | 1. Spinal Cord and Brain Injury Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America;2. Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America;3. Center for Animal Nutrigenomics and Applied Animal Nutrition, Alltech, Nicholasville, Kentucky, United States of America;University of Kentucky Medical Center, UNITED STATES |
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| Abstract: | Selenium is an essential element required for activity of several antioxidant enzymes, including glutathione peroxidase. Because of the critical role of the antioxidant system in responding to traumatic events, we hypothesized that dietary selenium supplementation would enhance neuroprotection in a rodent model of spinal cord injury. Rats were maintained on either a control or selenium-enriched diet prior to, and following, injury. Dietary selenium supplementation, provided as selenized yeast added to normal rat chow, resulted in a doubling of selenium levels in the spinal cord. Dietary selenium reduced the time required for recovery of bladder function following thoracic spinal cord injury. However, this was not accompanied by improvement in locomotor function or tissue sparing. |
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