Recent advances in N- and C-terminus cysteine protein bioconjugation |
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Affiliation: | Department of Chemistry, University College London, 20 Gordon Street, London, UK |
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Abstract: | Advances in the site-specific chemical modification of proteins, also referred to as protein bioconjugation, have proved instrumental in revolutionary approaches to designing new protein-based therapeutics. Of the sites available for protein modification, cysteine residues or the termini of proteins have proved especially popular owing to their favorable properties for site-specific modification. Strategies that, therefore, specifically target cysteine at the termini offer a combination of these favorable properties of cysteine and termini bioconjugation. In this review, we discuss these strategies with a particular focus on those reported recently and provide our opinion on the future direction of the field. |
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Keywords: | Cysteine conjugation N-terminal modification C-terminal modification Termini modification Protein modification Peptide modification |
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