Mechanism of action of cesalin, an antitumor protein. |
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Authors: | J Elting R Montgomery |
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Institution: | Department of Biochemistry University of Iowa Iowa City, Iowa 52242 USA |
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Abstract: | A protein, cesalin, isolated from is cytotoxic to KB cells in tissue culture. It has been shown to bind to the plasma membrane of this cell line and to inhibit Na+, K+-ATPase (ATP phosphohydrolase EC 3.6.1.3). Similar studies with HTC cells show no cytotoxicity or inhibition of plasma membrane Na+, K+-ATPase. The Na+, K+-ATPase of human erythrocytes and rat brain and kidney tissues are not inhibited. 5′-Nucleotidase and Mg++-ATPase are not inhibited by cesalin in any cells tested. |
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