Synthesis and anticancer activity of novel chiral D-glucose derived bis-imidazoles and their analogs. |
| |
| Authors: | C Zhou A Hassner |
| |
| Affiliation: | Department of Chemistry, Bar-Ilan University, 52900, Ramat-Gan, Israel. |
| |
| Abstract: | A series of novel D-glucose derived bis-imidazoles and their analogs, which possess potential in bioorganic and supramolecular chemistry, were designed and synthesized from methyl alpha-D-glucoside through protection, bis-bromination, N-alkylation and deprotection. All new compounds were characterized by HRMS, 1H, 13C and DEPT NMR spectroscopy as well as elemental analysis. The 1H-(1)H and 1H-(13)C 2D NMR spectra for some compounds were also recorded. Some regular features of 13C and 1H NMR spectra were summarized. The anticancer activity of some compounds was evaluated. |
| |
| Keywords: | |
|
|
