New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum |
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Authors: | Hosoya Takahiro Yamamoto Yukinori Uehara Yoshimasa Hayashi Masahiko Komiyama Kanki Ishibashi Masami |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Chiba University, Japan. |
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Abstract: | Two new bisindole alkaloids, 6-hydroxystaurosporinone (1) and 5,6-dihydroxyarcyriaflavin A (2) were isolated from field-collected fruit bodies of a myxomycete Lycogala epidendrum, along with eight known bisindoles (3-10). The structures of these new compounds were determined on the basis of spectroscopic data. Compounds 1 and 2 showed cytotoxicity against HeLa, Jurkat, and vincristine resistant KB/VJ300 cells, and compound 1, particularly, inhibited protein tyrosine kinase activity. |
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