Effect of High Dietary Copper on Somatostatin and Growth Hormone-Releasing Hormone Levels in the Hypothalami of Growing Pigs |
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Authors: | Wenyan Yang Jianguo Wang Lei Liu Xiaoyan Zhu Xiaoxu Wang Zhaoxi Liu Zhe Wang Lianyu Yang Guowen Liu |
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Institution: | (1) College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China;(2) College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi’an Road, Changchun, 130062, China; |
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Abstract: | This experiment was conducted to examine the effect of dietary copper supplementation on somatostatin (SS) and growth hormone-releasing
hormone (GHRH) mRNA expression levels in the hypothalami of growing pigs. A total of 45 crossbred pigs were randomly assigned
to three groups of 15 pigs each; five replicates of three animals comprised each group. Pigs were allocated to diets that
contained 5 mg/kg copper (control), 125 mg/kg copper sulfate, or 125 mg/kg copper methionine. At the end of the experiment,
five pigs were selected at random from each group and slaughtered, and hypothalami were collected for determination of SS
and GHRH mRNA expression levels. The results showed that the SS expression levels were lower and the GHRH levels were higher
in pigs fed the diets with 125 mg/kg copper methionine (P < 0.05) and 125 mg/kg copper sulfate (P < 0.05), respectively, than in pigs fed the diet with 5 mg/kg copper. Furthermore, the relationship between SS mRNA and GHRH
mRNA abundance had a significantly negative correlation (P < 0.05). The data indicated that high dietary copper could enhance GHRH mRNA expression levels and suppress SS mRNA expression
levels in the hypothalami of pigs. High lever dietary copper (125 mg/kg copper sulfate or 125 mg/kg copper methionine) increased
pigs’ growth performance and feed efficiency but had no significant effect on daily feed intake; 125 mg/kg copper sulfate
or 125 mg/kg copper methionine at the same lever had no difference on growth promoting in pigs. |
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