Increased entropy of signal transduction in the cancer metastasis phenotype |
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| Authors: | Andrew E Teschendorff Simone Severini |
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| Institution: | (1) Medical Genomics Group, Paul O'Gorman Building, UCL Cancer Institute, University College London, 72 Huntley Street, WC1E 6BT London, UK;(2) Department of Physics & Astronomy, University College London, WC1E 6BT London, UK |
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| Abstract: | Background The statistical study of biological networks has led to important novel biological insights, such as the presence of hubs
and hierarchical modularity. There is also a growing interest in studying the statistical properties of networks in the context
of cancer genomics. However, relatively little is known as to what network features differ between the cancer and normal cell
physiologies, or between different cancer cell phenotypes. |
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