An innovative lattice Boltzmann model for simulating Michaelis–Menten-based diffusion–advection kinetics and its application within a cartilage cell bioreactor |
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Authors: | A A Moaty Sayed M A Hussein T Becker |
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Institution: | 1. Technische Universit?t München (TUM), Life Science Engineering Department, Group of (Bio)-Process Technology and Process Analysis, Weihenstephaner Steig 20, 85354, Freising, Germany
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Abstract: | Lattice Boltzmann models (LBM) are rapidly showing their ability to simulate a lot of fluid dynamics problems that previously
required very complex approaches. This study presents a LBM for simulating diffusion–advection transport of substrate in a
2-D laminar flow. The model considers the substrate influx into a set of active cells placed inside the flow field. A new
innovative method was used to simulate the cells activity using the LBM by means of Michaelis–Menten kinetics. The model is
validated with some numerical benchmark problems and proved highly accurate results. After validation the model was used to
simulate the transport of oxygen substrates that diffuse in water to feed a set of active cartilage cells inside a new designed
bioreactor. |
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