SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells |
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| Authors: | Shuai Li Adam B Francisco Robert J Munroe John C Schimenti Qiaoming Long |
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| Affiliation: | (1) Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14850, USA;(2) Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA |
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| Abstract: | Background The vertebrate pancreas contains islet, acinar and ductal cells. These cells derive from a transient pool of multipotent pancreatic progenitors during embryonic development. Insight into the genetic determinants regulating pancreatic organogenesis will help the development of cell-based therapies for the treatment of diabetes mellitus. Suppressor enhancer lin12/Notch 1 like (Sel1l) encodes a cytoplasmic protein that is highly expressed in the developing mouse pancreas. However, the morphological and molecular events regulated by Sel1l remain elusive. |
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