新型机械心脏瓣膜的研究

目前临床使用的各种机械心脏瓣膜的主要问题是血栓栓塞和与抗凝治疗有关的出血，其缺陷在于瓣膜开启时，碟片和支架将瓣膜的整个血流通道分隔成三至四个较小的血流通道。在这种受阻隔的血流通宫，形成容易诱发血栓的高剪应力区、紊流和滞流区。我们研制的两种机械心脏瓣膜在瓣膜开启时，没有任何支架和碟片分隔瓣膜的血流通道，使血流与天然心脏瓣膜中的相类似，可减少对血液的危害，从而可减少换瓣病人对抗凝治疗的依赖程度。

Development of new mechanical heart valves

The major problems of current clinically-used mechanical heart valves are thromboembolism and hemorrhage related to anticoagulants. These mechanical heart valves are considered as being unsatifactory, because in the open position, the leaflets and struts divide the ring orifice of the valve into 3-4 regions. In this obstructive orifice, the high turbulent shear stresses and the region of flow separation and stagnation all give rise to the occurrence of thrombosis. In our design of mechanical heart valve, in the open position, no structural component or leaflet divides the ring orifice of the valve. Our mechanical heart valve has the best possibilities for creating more natural blood flow pattern which could creat minimal damage to blood elements and might reduce the need for anticoagulation therapy.