Tentative immunohistochemical demonstration of melatonin in the rat pineal gland |
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| Authors: | Dr. Dagmar Freund Josephine Arendt Lutz Vollrath |
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| Affiliation: | (1) Department of Anatomy, Johannes Gutenberg-Universität, Mainz, Germany;(2) Clinique Universitaire de Pédiatrie, Geneva, Switzerland;(3) Anatomisches Institut der Johannes Gutenberg-Universität Mainz, Saarstrasse 19/21, D-6500 Mainz |
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| Abstract: | Summary In the present study an attempt was made to demonstrate melatonin in the rat pineal gland by means of immunohistochemistry. The anti-body used was raised against 5-methoxy-N-acetyltryptophan which is chemically similar to melatonin. Specific fluorescence was demonstrable only in pineals from rats killed during the night, when melatonin formation is high. It was restricted to parenchymal cells lying in a marginal zone of the organ. These results are discussed in relation to a subdivision of the pineal parenchyma into cortical and medullary areas.Supported by a grant of the Deutsche Forschungsgemeinschaft (VO 135/4) within the  Schwerpunktprogramm Neuroendokrinologie |
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| Keywords: | Melatonin Immunohistochemistry Pineal gland Rat |
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