Effect of Toxocara canis infection on the ability of white rats to solve maze problems |
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| Authors: | L J Olson J E Rose |
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| Affiliation: | 1. Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt;2. Medical technology center, Medical Research Institute, Alexandria University, Egypt;3. Pharmacology department, Medical Research Institute, Alexandria university, Egypt;4. Chemical Pathology department. Medical Research institute. Alexandria University, Egypt;5. Department of Pathology, Theodor Bilharz Research Institute, Kornaish El-Nile St., 12411, Giza, Egypt;6. Department of Medical Parasitology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, 35516, Egypt;1. Medical Parasitology Department, Faulty of Medicine, Tanta University, Egypt;2. Biochemistry Division, Chemistry Department, Faculty of Science, Damanhour University, Egypt;3. Zoology Department, Faculty of Science, Tanta University, Egypt;4. Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt;5. Anatomy and Embryology Department, Faculty of Medicine, Tanta University, Egypt;6. Histopathology Department, Faculty of Medicine, Tanta University, Egypt;7. Physiology Department, Faculty of Medicine, Tanta University, Egypt;8. Biostatistics and Public Health Department, Faculty of Medicine, Menoufia University, Egypt;9. Medical Parasitology Subunit, Microbiology and Immunology Department, Faculty of Medicine, Mutah University, Jordan;10. Medical Parasitology Subunit, Pathology Department, College of Medicine, Jouf University, Sakaka, Saudi Arabia;1. School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA;1. Department of Orthopaedics, Affiliated Hospital 2 of Nantong University, Nantong 226001, People''s Republic of China;2. Institute of Reproductive Medicine, Medical College, Nantong University, Nantong 226001, People''s Republic of China;3. Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, People''s Republic of China |
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| Abstract: | Rats were orally infected with 5,000, 7,500, 20,000, and 33,000 infective Toxocara canis eggs. Paired controls were similarly treated except that the eggs were omitted from the inoculum. The ability of rats infected with 20- or 33,000 eggs to solve complex maze problems during the second week of infection was significantly reduced. Retesting of these rats during the fourth week revealed the persistence of a learning deficit, although percent reduction in total errors was equal to the control value. Other rats were tested on complex maze situations prior to infection with 20,000 eggs. The performance of these rats on retesting during the second week of infection was similar to that of controls. The migration patterns of these larvae in rats was found to be similar to that reported for mice; invasion of the brain commenced during the latter half of Week 1. The cerebral cortex and cerebellum were found to harbor the majority of larvae present in the brain. |
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