Antigenic profiles of human,bovine and canine articular chondrocytes |
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Authors: | Dr. T. Giant K. Mikecz |
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Affiliation: | (1) Institute of Anatomy, Histology and Embryology, University of Medicine, Debrecen, Hungary;(2) Department of Internal Medicine III, University of Medicine, Debrecen, Hungary;(3) Institute of Anatomy, Histology and Embryology, University of Medicine, H-4012 Debrecen, Hungary |
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Abstract: | Summary Human, bovine and canine articular chondrocytes have been shown to bear cartilage matrix, chondrocyte-specific and histocompatibility antigens. These cell-surface antigens of chondrocytes were demonstrated both simultaneously and separately either by complement-mediated cytotoxicity or by immunohistochemical reactions. The chondrocyte-specific antigens involve subsets of species-common and species-specific determinants, which are also present on the surfaces of rib and laryngeal chondrocytes. In addition to these antigens, human and calf articular chondrocytes also express unique cell-surface components that are capable of producing a blastogenic stimulation of autologous T-lymphocytes in vitro. These putative autoantigens segregated from lymphocytes in vivo could be released in trauma and in inflammatory joint diseases triggering the immune system of the host. |
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Keywords: | Chondrocytes Lymphocytes Chondrocyte antigens Mixed lymphocyte cultures Immunohistochemstry Mammals |
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