| 外源性磷酸肌酸临床效果观察 |
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| 引用本文： | 胡克俭 叶磊. 外源性磷酸肌酸临床效果观察[J]. 上海生物医学工程, 2000, 21(1): 47-49 |
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| 作者姓名： | 胡克俭 叶磊 |
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| 作者单位： | 上海医科大学中山医院心外科，上海市心血管病研究所 200032 |
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| 摘 要： | 研究磷酸肌酸对缺血／再灌注损伤心肌的保护作用。方法对２０例进行双瓣膜替换术的患者，随机分成两组：实验组和对照组；分别于主动脉阻断前，开放后２、２４、４８小时抽血测定ＡＳＴ，ＬＤＨ，ＣＫ－ＭＢ，ＣＫ－ＭＭ和ｃＴｎｔ。结果主动脉开放后２小时实验组各指标均明显低于对照组；２４时达峰值。
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| 关 键 词： | 磷酸肌酸 心肌保护 外源性 心肌缺血 |
Clinical Observation the effect of Exogenous Creatine Phosphate |
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| Zhongshan Hospital Shanghai Medical University. Clinical Observation the effect of Exogenous Creatine Phosphate[J]. Shanghai Journal of Biomedical Engineering, 2000, 21(1): 47-49 |
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| Authors: | Zhongshan Hospital Shanghai Medical University |
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| Abstract: | Objective:To study the effect of Creatine Phosphate on myocardium after Is-chemia/Reperfusion. Method: Twenty patients were involved and divided into two groups: experiment group ( creatine phosphate cardioplegia ), control group ( crystalloid cardioplegia). Before aortia crossclamping, and 2, 24,48 hours after uncrossclamping, blood were taken to measure the concentrations of AST, LDH, CK, CK-MB, CK-MM and cTnT. Result: 2 hours after uncrossclamping, all the markers in control group rose higher than those in experiment group (P<0. 01-0. 001). Conclusion:Creatine phosphate provide energy for cells, protect the cell's membrane and contractive protein. It is sure that Creatine Phosphate can relieve the ischemia reperfusion injury. |
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| Keywords: | Creatin phosphate Myocardial protection |
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