Improved predictions by Pcons.net using multiple templates |
| |
Authors: | Larsson Per Skwark Marcin J Wallner Björn Elofsson Arne |
| |
Institution: | Center for Biomembrane Research, Department of Biochemistry and Biophysics, Swedish e-Science Research Centre, Stockholm Bioinformatics Centre, SciLifeLab, Stockholm University SE-10691 Stockholm, Sweden. |
| |
Abstract: | Multiple templates can often be used to build more accurate homology models than models built from a single template. Here we introduce PconsM, an automated protocol that uses multiple templates to build protein models. PconsM has been among the top-performing methods in the recent CASP experiments and consistently perform better than the single template models used in Pcons.net. In particular for the easier targets with many alternative templates with a high degree of sequence identity, quality is readily improved with a few percentages over the highest ranked model built on a single template. PconsM is available as an additional pipeline within the Pcons.net protein structure prediction server. AVAILABILITY AND IMPLEMENTATION: PconsM is freely available from http://pcons.net/. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|