Transgenic rescue of Atg5-null mice from neonatal lethality with neuron-specific expression of ATG5: Systemic analysis of adult Atg5-deficient mice |
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| Authors: | Saori R Yoshii Akiko Kuma |
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| Institution: | 1. Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan;2. Japan Science and Technology Agency, PRESTO, Saitama, Japan |
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| Abstract: | Atg5-null mice are neonatal lethal. We have revealed in our recent paper that these mice die due to neuronal dysfunction resulting in suckling failure. Our new mouse model, atg5–/–;Eno2/Nse-Atg5 mice, where Atg5 is deficient in the whole body except for neurons, enables us to analyze the consequences of macroautophagy/autophagy-deficiency in the whole body of adult mice. |
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| Keywords: | ATG5 autophagy deficiency hypogonadism iron deficiency neonatal lethality neuronal dysfunction suckling failure systemic analysis |
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