Pas1 is a common lung cancer susceptibility locus in three mouse strains |
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Authors: | Giacomo Manenti Manuela Gariboldi Antonio Fiorino Antonio I. Zedda Marco A. Pierotti Tommaso A. Dragani |
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Affiliation: | (1) Division of Experimental Oncology A, Istituto Nazionale Tumori, Via G. Venezian 1, 20133, Milan, Italy, IT |
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Abstract: | Inherited predisposition to lung cancer is a phenotypic trait shared by different mouse inbred strains that show either a high or an intermediate predisposition. Other strains are instead genetically resistant. The Pas1 locus is the major determinant of lung cancer predisposition in the A/J strain (Gariboldi et al. 1993). To define the determinants of susceptibility to lung tumorigenesis in the highly susceptible SWR/J and in the intermediately susceptible BALB/c mice, we analyzed (BALB/c × SWR/J)F2 and (BALB/c × C3H/He)F2 crosses by genetic linkage experiments. The present results provide unequivocal evidence that the same Pas1/+ allele that leads to lung cancer predisposition is shared by A/J, SWR/J, and BALB/c strains. The intermediate susceptibility of the BALB/c strain would result by interaction of Pas1 locus with lung cancer resistance loci. Received: 18 April 1997 / Accepted: 15 June 1997 |
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