Metabolism of cyclic AMP in non-pathogenic Mycobacterium smegmatis |
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| Authors: | C H Lee |
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| Institution: | (1) Department of Clinical Biochemistry, Faculty of Medicine, University of Otago, Dunedin, South Island, New Zealand;(2) Present address: Department of Biochemistry and Microbiology, University of Agriculture Malaysia, Serdang, Selangor, Malaysia |
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| Abstract: | The intracellular concentration of cyclic AMP reached a maximum in 3.5-day old cultures of Mycobacterium smegmatis grown in the presence of glycerol as the main source of carbon. Glucose-grown cells exhibited decreased cyclic AMP levels at all stages of growth. When M. smegmatis cells were incubated with various metabolites, pyruvate increased whereas glucose, citric acid, succinic acid and lactic acid decreased intracellular cyclic AMP levels. No cyclic AMP was detected in the incubation medium. The presence of a cyclic AMP-binding protein was demonstrated in cellfree extracts of M. smegmatis. |
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| Keywords: | Mycobacterium smegmatis Intracellular cyclic Growth conditions Cyclic AMP-binding protein |
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