|
|||||
|
|
Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues |
|
| Authors: | Li James J Wang Haixia Qu Fucheng Musial Christa Tino Joseph A Robl Jeffrey A Slusarchyk Dorothy Golla Rajasree Seethala Ramakrishna Dickinson Kenneth Giupponi Leah Grover Gary Sleph Paul Flynn Neil Murphy Brian J Gordon David Kung Melissa Stoffel Robert |
| Institution: | Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543, USA. |
| Abstract: | Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |