Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy |
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| Authors: | Séverine Lorin Marc J. Tol Chantal Bauvy Anneke Strijland Christian Poüs Arthur J. Verhoeven Patrice Codogno Alfred J. Meijer |
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| Affiliation: | 1.EA4530; Faculty of Pharmacy; University Paris-Sud; Châtenay-Malabry, France;2.Department of Medical Biochemistry; Academic Medical Center; University of Amsterdam; Amsterdam, The Netherlands;3.INSERM U845; University Paris-Descartes; Paris, France;4.Department of Biochemistry; Antoine Béclère Hospital AP-HP; Clamart; France |
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| Abstract: | Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species. |
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| Keywords: | reactive oxygen species NADPH amino acids signaling mitochondria MTOR AMPK transhydrogenase |
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