MTOR overactivation and interrupted autophagy flux in obese hearts |
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Authors: | Yingmei Zhang Xihui Xu Jun Ren |
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Institution: | 1.Center for Cardiovascular Research and Alternative Medicine; University of Wyoming, Laramie, WY USA;2.Department of Cardiology; Xijing Hospital; Fourth Military Medical University; Xi''an, China |
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Abstract: | As a central controller of cell growth, mechanistic target of rapamycin (MTOR) affects an array of biological processes, in particular protein synthesis, autophagy and cardiac homeostasis. Conflicting findings have been seen with regard to the role of MTOR signaling and autophagy in cardiac and adipocyte function under metabolic syndrome. AKT, an essential insulin-signaling molecule upstream of MTOR, participates in the regulation of glucose homeostasis and cardiac metabolism. Akt2 knockout may rescue against high-fat diet-disrupted autophagy flux, en route to cardioprotection. Thus, inhibition of MTOR may serve as a possible avenue to retard pathological cardiac hypertrophy via rescuing interrupted autophagic flux. |
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Keywords: | obesity autophagy Akt MTOR cardiac function |
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