The role of autophagy in plasma cell ontogenesis |
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| Authors: | Niccolò Pengo Simone Cenci |
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| Institution: | 1.MRC LMCB; University College London; London, UK;2.Division of Genetics and Cell Biology; San Raffaele Scientific Institute and University Vita-Salute San Raffaele; Milan, Italy |
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| Abstract: | We have identified in plasma cells a novel ATG5-dependent selective negative control on the secretory pathway, which restricts antibody production, sustaining energy metabolism. Revealing new immune functions, autophagy is required in vivo for antibody responses and to maintain the memory plasma cell compartment. |
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| Keywords: | antibody autophagy Blimp-1 bone marrow immunity immunological memory niche plasma cell unfolded protein response XBP-1 |
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