Transposition of the gene cluster CYC1-OSM1-RAD7 in yeast |
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Authors: | John I Stiles Linda R Friedman Cynthia Helms Sandra Consaul Fred Sherman |
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Institution: | Department of Radiation Biology and Biophysics University of Rochester School of Medicine and Dentistry Rochester, N.Y. 14642, U.S.A. |
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Abstract: | A mutant of the yeast Saccharomyces cerevisiae contains an increased amount of iso-1-cytochrome c because two copies of a segment, denoted COR, were transposed to a new position on chromosome VII, while the original COR region was retained at the normal position on chromosome X; this COR segment encompasses the CYC1, OSM1 and RAD7 loci which determine, respectively, iso-1-cytochrome c, osmotic sensitivity and ultraviolet light sensitivity. The analysis of genomic DNA with cloned probes indicates that the length of the COR segment is approximately 12,000 base-pairs. We suggest that certain normal strains of yeast, which possibly may contain reiterated sequences, can produce extended transpositions similar to prokaryotes. |
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