Rapid differentiation of <Emphasis Type="Italic">Francisella</Emphasis> species and subspecies by fluorescent in situ hybridization targeting the 23S rRNA |
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| Authors: | Wolf D Splettstoesser Erik Seibold Ella Zeman Karlheinz Trebesius Andreas Podbielski |
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| Institution: | (1) German Reference Laboratory for Tularemia, Bundeswehr Institute of Microbiology, Neuherbergstr 11, 80937 Munich, Germany;(2) University of Applied Sciences Munich, Lothstr. 34, 80335 Munich, Germany;(3) Department of Microbiology, Virology & Hygiene, University Hospital Rostock, Schillingallee 70, 18057 Rostock, Germany |
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| Abstract: | Background
Francisella (F.) tularensis is the causative agent of tularemia. Due to its low infectious dose, ease of dissemination and high case fatality rate, F. tularensis was the subject in diverse biological weapons programs and is among the top six agents with high potential if misused in
bioterrorism. Microbiological diagnosis is cumbersome and time-consuming. Methods for the direct detection of the pathogen
(immunofluorescence, PCR) have been developed but are restricted to reference laboratories. |
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