The plasma membrane of human erythrocyte with different levels of glucose-6-phosphate dehydrogenase. |
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| Authors: | A Afolayan |
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| Affiliation: | 1. School of Materials Science and Technology, Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, China University of Geosciences, Beijing 100083, PR China;2. School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, PR China;1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China;4. Institute of Environment and Health, Jianghan University, Wuhan 430056, China;1. Sustainability and Quality Group of Fruit and Vegetable Products, Murcia Institute of Agri-Food Research and Development, C/ Mayor S/n, La Alberca, 30150, Murcia, Spain;2. Department of Agricultural Chemistry, Geology and Pedology, Faculty of Chemistry, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain;1. Center for Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea;2. University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea;3. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza 12566, Egypt;4. Medicinal & Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Giza 12622, Egypt;5. Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea;6. College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea;7. Center for Neuro-Medicine, Korea Institute of Science & Technology (KIST School), Seoul, Seongbuk-gu, 02792, Republic of Korea;8. Department of Beauty Science, Hanseo University, Seosan 31962, Republic of Korea |
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| Abstract: | - 1.1. The erythrocyte ghosts from red cells having normal or deficient level of glucose-6-phosphate dehydrogenase have been prepared.
- 2.2. The two types of ghosts appear similar in the size and distribution of polypeplides and glyco-proteins.
- 3.3. However, chemical modification and fluorescence studies in the presence of primaquine and chloroquine suggest a possible difference in structure between the two types of ghost.
- 4.4. Generally, the ghost from red cell with defficient G6PD is more perturbed by antimalarial drugs.
- 5.5. This result may explain why carriers of this deficient enzyme have their red cells readily haemolysed on consumption of antimalarial drugs.
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