Position of Igl-1, md,and Bst loci on chromosome 16 of the mouse

The experiments described here delineate the position of the chromosome 16 markers Igl-1(immunoglobulin ₁ light chain), md (mahoganoid), and Bst (belly spot and tail), and suggest their location relative to the endogenous proviral locus Akv-2, which is linked within 5.9 centimorgans to Igl-1 (Epstein et al. 1984). The data from an intercross and a three-point backcross detailed herein show the order of these three genes and distances between them to be: centromere-md –10.4 ± 1.6 - Igl-1 –15.6 ± 2.6 - Bst. Using a recombinant chromosome recovered in the intercross, we have constructed a stock homozygous for md and Igl-1^b(KpnI^–), that will aid in mapping other genes on chromosome 16.In previous publications, alleles at the structural locus have been referred to as + and –. To conform to standard mouse nomenclature, we propose here the allele symbols a for + and b for –. We refer to genes encoding immunoglobulin molecules (i. e., v, c) in lower case letters, while the gene products are capitalized