mRNA localization: motile RNA, asymmetric anchors |
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| Authors: | Bloom K Beach D L |
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| Affiliation: | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. Kerry_Bloom@unc.edu |
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| Abstract: | Techniques to label mRNA with green fluorescent protein (GFP) have provided the first real-time images of RNA motility in live yeast cells. Genetic screens for factors responsible for mRNA asymmetry (e. g. SHE genes) in yeast identified type V myosin among other proteins. Analysis of mRNA movement in various she mutants revealed the role of motor proteins in long-range transport, factors for particle formation, and cortical anchors for docking the mRNA. |
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| Keywords: | Motile RNA Asymmetric anchors GFP RNA localization ASH1 mRNA Formin homology Cytoskeleton |
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