Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents |
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Authors: | Kumar Vivek Mudgal Mukesh M Rani Nidhi Jha Amrita Jaggi Manu Singh Anu T Sanna Vinod K Singh Pratibha Sharma Pramod K Irchhaiya Raghuveer Burman Anand C |
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Institution: | Chemical Research, Dabur Research Foundation, 22, Site IV, SahibabadGhaziabad, 201 010, UP, India. kumarv@dabur.com |
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Abstract: | A new series of functionalized amino acid derivatives N-substituted 1-N-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyl-5-oxazolidine carboxamide (1-17) and 1-N-substituted-3-amino-2-hydroxy-3-phenylpropane-1-carboxamide (18-34) were synthesized and evaluated for their in vitro cytotoxicity against human cancer cell lines. Compound 6 has shown interesting cytotoxicity (IC(50) = 5.67 microm) in ovarian cancer, while compound 10 exhibited promising cytotoxicity in ovarian (IC(50) = 6.1 microm) and oral (IC(50) = 4.17 microm) cancers. These compounds could be of use in designing new anti-cancer agents. |
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