Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites |
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Authors: | Al-Aboudi Amal Odeh Hana Khalid Asaad Naz Qamar Choudhary M Iqbal |
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Affiliation: | Department of Chemistry, University of Jordan, Amman, Jordan. alaboudi@ju.edu.jo |
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Abstract: | Testosterone and ten of its metabolites were examined as inhibitors of butyrylcholinesterase. A significant enzyme inhibition activity (IC(50) = 1.55 microM) was observed for androst-4-en-3,7-dione. The kinetic parameters of butyrylcholinesterase inhibition were determined and molecular docking was carried out in order to develop a better understanding of the inhibitor-enzyme interactions. The results showed that the inhibition was non-competitive, stabilized mainly by hydrogen bonds and hydrophobic interactions between the inhibitor and butyrylcholinesterase. |
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