The lymphocyte plasma membrane: Locus of control in the immune response |
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Authors: | L M Jerry A K Sullivan |
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Institution: | (1) Cancer Research Unit and Department of Experimental Medicine, McGill University, H3C-3G1 Montreal, Quebec, Canada |
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Abstract: | Summary The lymphocyte plasma membrane is the locus of events which control the immune response. T and B lymphocytes, which mediate
cellular and humoral immunity respectively, show distinctive plasma membrane morphologies and cell surface receptors. The
dynamic state of these plasma membrane components is emphasized by their lateral mobility in the fluid plane of the membrane,
as well as variation in their structure or expression as the lymphocyte proliferates and differentiates in response to stimulation
by antigen or mitogens. The best understood membrane glycoproteins are surface membrane immunoglobulins that serve as antigen
receptors on B cells, and the histocompatability-β
2 microglobulin complex that has an immunoglobulin-like structure. Other less well defined surface structures showing modulation
during the cell cycle may affect growth regulation of proliferating lymphocytes. Some of these are shared by fetal and neoplastic
cells. Major theories of lymphocyte signaling are discussed, and the early events in lymphocyte activation are reviewed. While
a complete model encompassing all these early events is not yet possible, the central issues can be usefully discussed in
terms of receptor-transducer-effector concepts derived by strong parallels from a knowledge of hormone-membrane interactions.
Presented in the formal symposium on Information Transfer in Eukaryotic Cells, at the 26th Annual Meeting of the Tissue Culture
Association, Montreal, Quebec, June 2–5, 1975.
Supported by: Medical Research Council of Canada and National Cancer Institute of Canada.
Scholar of the Medical Research Council of Canada. |
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Keywords: | lymphocyte plasma membrane membrane glycoproteins immunoglobulin histocompatability antigens lymphocyte activation |
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