Class and subclass selection in parasite-specific antibody responses |
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Authors: | Garraud Olivier Perraut Ronald Riveau Gilles Nutman Thomas B |
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Affiliation: | Groupe Immunité des Muqueuses et Agents pathogènes EA-3064, Faculté de Médecine, Université de Saint-Etienne, 15 rue Ambroise Paré, 42023 cedex 02, Saint-Etienne, France. olivier.garraud@univ-st-etienne.fr |
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Abstract: | Antibodies are characteristically induced in many parasitic infection processes. The class and subclass of the antibody response is instrumental because each isotype has a distinct biological function. It is thus crucially important for an infected individual to mount the most appropriate secondary antibody response--that is the response that has the best chance of clearing the infection and/or controlling disease. This represents a fundamental of vaccine strategies. Immuno-epidemiological surveys and in vitro models of antibody production have helped to understand some of the goals which should be achieved when designing antiparasitic vaccines. |
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