Computational simulation of simultaneous cortical and trabecular bone change in human proximal femur during bone remodeling |
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| Authors: | In Gwun Jang Il Yong Kim |
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| Affiliation: | 1. Department of Ocean Systems Engineering, Korea Advanced Institute of Science and Technology, 373-1, Guseong-dong, Yuseong-gu, Daejon 305-701, South Korea;2. Department of Mechanical and Materials Engineering, McLaughlin Hall 305, 130 Stuart Street, Queen''s University, Kingston, Ontario, Canada K7L 3N6;1. Multiscale in Mechanical and Biological Engineering (M2BE), Aragón Institute of Engineering Research (I3A), Mechanical Engineering Department, University of Zaragoza, Spain;2. Laboratory for Biomechanical Engineering, University of Twente, Enschede, The Netherlands;3. Radboud University Medical Center, Radboud Institute for Health Sciences, Orthopaedic Research Laboratory, Nijmegen, The Netherlands;4. Biomedical Engineering Department, Materialise NV, Leuven, Belgium;1. School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW 2006, Australia;2. School of Civil and Environmental Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia;2. Menzies Research Institute of Tasmania, University Of Tasmania, Hobart, Tasmania 7000, Australia;3. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia;1. Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands;2. Institute for Biomechanics, ETH Zurich, Zurich, Switzerland;1. Multiscale in Mechanical and Biological Engineering (M2BE), Aragón Institute of Engineering Research (I3A), University of Zaragoza, Spain;2. Centro Universitario de la Defensa, Academia General Militar, Zaragoza, Spain |
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| Abstract: | In this study, we developed a numerical framework that computationally determines simultaneous and interactive structural changes of cortical and trabecular bone types during bone remodeling, and we investigated the structural correlation between the two bone types in human proximal femur. We implemented a surface remodeling technique that performs bone remodeling in the exterior layer of the cortical bone while keeping its interior area unchanged. A micro-finite element (μFE) model was constructed that represents the entire cortical bone and full trabecular architecture in human proximal femur. This study simulated and compared the bone adaptation processes of two different structures: (1) femoral bone that has normal cortical bone shape and (2) perturbed femoral bone that has an artificial bone lump in the inferomedial cortex. Using the proposed numerical method in conjunction with design space optimization, we successfully obtained numerical results that resemble actual human proximal femur. The results revealed that actual cortical bone, as well as the trabecular bone, in human proximal femur has structurally optimal shapes, and it was also shown that a bone abnormality that has little contribution to bone structural integrity tends to disappear. This study also quantitatively determined the structural contribution of each bone: when the trabecular adaptation was complete, the trabecular bone supported 54% of the total load in the human proximal femur while the cortical bone carried 46%. |
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