|
|||||
|
|
Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice |
|
| Authors: | Mai Akiho Hiroyuki Nakashima Munehiro Sakata Yuka Yamasa Akihiko Yamaguchi Kunihiro Sakuma |
| Institution: | 1. Research Center for Physical Fitness, Sports and Health, Toyohashi, University of Technology, 1-1 Hibarigaoka, Tenpaku-cho, Toyohashi, 441-8580, Japan;2. Department of Legal Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan;3. School of Dentistry, Health Sciences University of Hokkaido, Kanazawa, Ishikari-Tobetsu, Hokkaido, Japan |
| Abstract: | AimWe investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice.Main methodsWe performed immunofluorescence of both Notch-1 and the Notch-1-linking molecules.Key findingsImmunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2–6. We observed clear co-localization between Notch-1 and myogenin (4.9 ± 1.3%) in the hypertrophied muscle at 4 days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1 ± 1.2%).SignificanceNotch-1 may play an important role in the maintenance of quiescent satellite cells. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |