Temperature-dependent threshold shear stress of red blood cell aggregation |
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| Authors: | Hyun-jung Lim Yong-Jin Lee Jeong-Hun Nam Seok Chung Sehyun Shin |
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| Institution: | 1. Key Laboratory of Metastable Materials Science and Technology, College of Science, Yanshan University, Qinhuangdao 066004, PR China;2. Laboratory of Optical Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, PR China;1. Dept. of Electrical & Electronic Engineering, Rajshahi University of Engineering & Technology, Rajshahi 6204, Bangladesh;2. Dept. of Electronics & Telecommunication Engineering, Rajshahi University of Engineering & Technology, Rajshahi 6204, Bangladesh;1. College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China;2. National Engineering Research Center of Chemical Fertilizer Catalyst, Fuzhou 350002, China;3. Fujian Key Lab of Medical Instrument and Pharmaceutical Technology, Fuzhou 350002, China;1. Department of Chemistry, Purdue University, West Lafayette, IN;2. Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD;3. Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;4. Embryonic Stem Cell and Transgenic Mouse Core Facility, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD |
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| Abstract: | Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which exhibits a unique temperature dependence. However, further investigation is still required for understanding the temperature-dependent characteristics of hemorheology that includes RBC aggregation. In the present study, blood samples were examined at 3, 10, 20, 30, and 37 °C. When the temperature decreases, the whole-blood and plasma viscosities increase, whereas the aggregation indices (AI, M, and b) yield contrary results. Since these contradictory results are known to arise from an increase in the plasma viscosity as the temperature decreases, aggregation indices that were corrected for plasma viscosity were examined. The corrected indices showed mixed results with the variation of the temperature. However, the threshold shear rate and the threshold shear stress increased as the temperature decreased, which is a trend that agrees with that of the blood viscosity. As the temperature decreases, RBC aggregates become more resistant to hydrodynamic dispersion and the corresponding threshold shear stress increases as does the blood viscosity. Therefore, the threshold shear stress may help to better clarify the mechanics of RBC aggregation under both physiological and pathological conditions. |
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