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In vitro model of a semicircular canal: Design and validation of the model and its use for the study of canalithiasis |
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| Authors: | Dominik Obrist Stefan Hegemann Dominique Kronenberg Oliver Häuselmann Thomas Rösgen |
| Institution: | 1. ENT Unit, Department of Surgery, Arcispedale Santa Maria Nuova, Azienda USL - Center for Clinical and Basic Research (IRCCS), viale Risorgimento 80, 42123 Reggio Emilia, Italy;2. Audiology & Vestibology Service, Centromedico, Viale Officina 7, 6500 Bellinzona, Switzerland;3. ENT & Audiology Unit, Department of Experimental Diagnostic and Specialty Medicine (DIMES), S. Orsola - Malpighi University Hospital, Via Massarenti 9, 40138 Bologna, Italy |
| Abstract: | We present an experimental model for a semicircular canal with canalithiasis. Canalithiasis is a pathological condition where free-floating particles disturb the flow field in the semicircular canals. It may lead to a specific form of vertigo known as BPPV or top-shelf vertigo. A careful scaling of the physical and geometrical parameters allows us to study the mechanics of this disease on an enlarged model of a single semicircular canal with laser vibrometry and video particle tracking. Early results confirm the proper operation of the model canal and support the current theories on the mechanisms of BPPV. |
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