Computational analysis of flow structure and particle deposition in a single asthmatic human airway bifurcation |
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| Authors: | Honglin Zhang George Papadakis |
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| Affiliation: | 1. Department of Mechanical Engineering, King’s College London, Strand Campus, London WC2R 2LS, UK;2. NIHR Comprehensive Biomedical Research Centre at Guy''s and St Thomas'' NHS Foundation Trust, UK;1. State Key Laboratory of Multiphase Flow in Power Engineering, Xi?an Jiaotong University, Xi?an 710049, PR China;2. Bioinspired Engineering & Biomechanics Center, Xi?an Jiaotong University, Xi?an 710049, PR China;3. Bio-Acoustic MEMS in Medicine (BAMM) Lab, Division of Biomedical Engineering and Division of Infectious Diseases, Department of Medicine, Brigham & Women?s Hospital, Harvard Medical School, MA 02139, USA;4. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi?an Jiaotong University, Xi?an 710049, China;5. Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA;6. Department of Radiology, Stanford University School of Medicine, Canary Center for Early Cancer Detection, Palo Alto, CA 94304, USA;1. Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children''s Hospital, 700 Children''s Drive, Suite WB4154, Columbus, OH, 43205, USA;2. Department of Pediatric Surgery, Nationwide Children''s Hospital, 700 Children''s Drive, Columbus, OH, 43205, USA;3. Department of Otolaryngology Head and Neck Surgery, The Ohio State University, 915 Olentangy River Rd # 4000, Columbus, OH, 43212, USA;4. Department of Pediatric Otolaryngology Head and Neck Surgery, Nationwide Children''s Hospital, 700 Children''s Drive, Columbus, OH, 43205, USA;5. Department of Surgery, The Ohio State University, Wexner Medical Center, 395 W. 12th Ave., Suite 670, Columbus, OH, 43210, USA;1. Earth Simulator Center, Japan Agency for Marine-Earth Science and Technology, 3173-25 Showa-machi, Kanazawa-ku, Yokohama, Kanagawa 236-0001, Japan;2. Department of Aeronautics, Imperial College London, SW7 2AZ, UK;1. Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftungsprofessur for Nanomedicine, University Hospital Erlangen, Erlangen, Germany;2. Chair of Magnetofluiddynamics, Measuring and Automation Technology, Technische Universität Dresden, Dresden, Germany |
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| Abstract: | This paper aims to improve current understanding of flow structure and particle deposition in asthmatic human airways. A single, symmetric airway bifurcation, corresponding to generations 10–11 of Weibel’s model, is investigated through validated numerical simulations. The parent airway segment is modelled as a smooth circular tube. The child segments are considered asthmatic and their cross-section is modelled as a constricted tube with sinusoidal folds uniformly distributed along the circumference. The flow structure and particle deposition pattern for normal (i.e., healthy) and asthmatic airway bifurcations are compared and discussed. The numerical results reveal that the secondary flow in the asthmatic airway bifurcation is much stronger than in the healthy one, resulting in higher particle deposition. The effects of size of the lumen area and number of folds on particle deposition and pressure drop are also investigated. It is found that particle deposition efficiency is significantly affected by lumen area of the asthmatic segment (the smaller the lumen area, the higher the particle deposition efficiency). The effect of number of folds is small. Particle deposition efficiency also increases with Reynolds number. The pressure drop in the asthmatic airway bifurcation depends mainly on size of the lumen area. The effect of number of folds becomes important for strongly collapsed airways. |
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