FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. |
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| Authors: | M H Xie I Holcomb B Deuel P Dowd A Huang A Vagts J Foster J Liang J Brush Q Gu K Hillan A Goddard A L Gurney |
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| Institution: | Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. |
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| Abstract: | We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line. |
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