Modulation of natural killer activity by thymosin alpha 1 and interferon |
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Authors: | Cartesio Favalli Teresa Jezzi Antonio Mastino Cristina Rinaldi-Garaci Carlo Riccardi Enrico Garaci |
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Affiliation: | (1) Department of Experimental Medicine, Faculty of Medicine, II University of Rome, via Orazio Raimondo I-00173, Rome, Italy;(2) Institute of General Pathology, University of Rome, Rome, Italy;(3) Institute of Pharmacology, University of Perugia, Perugia, Italy |
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Abstract: | Summary A single injection of ![agr](/content/g06k527h885q5v67/xxlarge945.gif) -interferon (![agr](/content/g06k527h885q5v67/xxlarge945.gif) -IFN) (30 000 units/mouse), a major biological modifier of natural killer (NK) cytolytic activity, strongly stimulated NK activity in normal mice, as expected, while the same treatment did not statistically alter the NK response in cyclophosphamide (CY)-suppressed animals.We investigated the possibility of thymosin 1 cooperating with ![agr](/content/g06k527h885q5v67/xxlarge945.gif) -IFN in boosting NK activity in CY-suppressed animals.The results show that treatment with thymosin 1 (200 g/kg) for 4 days, followed by a single injection of ![agr](/content/g06k527h885q5v67/xxlarge945.gif) -IFN 24 h before testing, strongly restored NK activity in CY-suppressed mice. Thymosin 1 was, moreover, able to accelerate the recovery rate of NK activity in bone marrow reconstituted murine chimeras.Taken together the data support the concept that the synergic effect between thymosin 1 and ![agr](/content/g06k527h885q5v67/xxlarge945.gif) -IFN could be the result of effects on differentiation of the NK lineage at different levels. |
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