丽珠肠乐治疗溃疡性结肠炎的临床疗效及病理变化的研究

目的:探讨溃疡性结肠炎的微生态学改变及双歧杆菌对溃疡性结肠炎的预防和治疗作用.方法:随机选取溃疡性结肠炎的患者60人,分成二组.治疗组:口服丽珠肠乐胶囊;对照组:口服氟哌酸胶囊,柳氮磺胺吡啶栓直肠给药.疗程一个月.结果:溃疡性结肠炎的肠道内细菌数量双歧杆菌、乳杆菌显著下降(P＜0.01),肠球菌显著增加(P＜0.01).经丽珠肠乐治疗后,肠道内主要细菌的数量恢复正常,与对照组相比差异有显著性(P＜0.01);肠道黏膜病理及组织学改变基本恢复正常;临床症状改善上治疗组疗效高于对照组(P＜0.01).结论:双歧杆菌活菌制剂治疗溃疡性结肠炎效果显著,值得临床推广使用.

Studies on the microecological changes and the prevention and therapy by Bifidobacterium of ulcerative colitis

Objective:To study the microecological changes and the prevention and therapy by Bifido bacterium (BF) of ulcerative colitis.Methods:60 cases were randomly divided two grous.Therapeutic group was given by oral BF.Control norfloxacin and suppository Sulfasalazine.Results:The quantities of main bacteria in Ulcerative colitis such as Bifidobacterium and Lactobacillas decreased(P<0.01),while Enterococcus increased comparing with the control group(P<0.01).In Bifido bacterium the quantities of the intestines main bacteria such as Bifido bacterium and Lactobaccillus increased (P<0.01),while Enterococcus decreased with the control(P<0.01).Pathologic and Ultrastructral observations showed the structure of intestines mucosa were restored to normal.Clinical symptom was significantly improved in therapeutic group compared with control group(P<0.01).Conclusion:It was very good that effect of therapy of Ulcerative colitis with BF.