The effect of sulfinpyrazone on the response to sympathetic nervous system stimulation |
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| Affiliation: | 1. Department of Water Resources Development and Management, Indian Institute of Technology Roorkee, Uttarakhand, 247667, India;2. Department of Hydrology, Indian Institute of Technology Roorkee, Uttarakhand, 247667, India;1. Department of Physiology and Nutrition, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay;2. Neuroscience Program & Department of Psychology, Michigan State University, East Lansing, MI 48824, USA;1. School of Big-Data Science, Zhejiang University of Science and Technology, Hangzhou 310023, China;2. Network and Information Security Laboratory of Hangzhou Hikvision Digital Technology Co., Ltd. Hang Zhou 310052, China;3. Cyberspace Institute of Advanced Technology (CIAT), Guangzhou University, Guangzhou 510006, China;4. College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China;5. School of Information and Electronic Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China |
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| Abstract: | The purpose of this study was to determine if sulfinpyrazone has a direct action on sympathetic nerve endings to prevent release of the transmitter. Pre-synaptic and post-synaptic events as well as direct sympathetic nervous system stimulation were tested in 15 α-chloralose anesthetized cats before and 1 hour after sulfinpyrazone (100 mg·kg−1, i.v.). Heart rate response to cardiac accelerator nerve stimulation or to increasing doses of isoproterenol was not significantly depressed by sulfinpyrazone. In addition, no alteration in the reflex activation of the sympathetic nervous system in response to histamine was observed following sulfinpyrazone. Both norepinephrine and epinephrine levels were similar to those levels reported previously by Smith and Robinson (7) for untreated cats. We conclude sulfinpyrazone has no direct depressing effect on the sympathetic nerve endings and that this mechanism cannot explain the reported beneficial effect of sulfinpyrazone on coronary occlusion induced arrhythmias. |
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