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The production of hydroxyl radical from copper(I) complex systems of bleomycin and tallysomycin: comparison with copper(II) and iron(II) systems. |
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| Authors: | Y Sugiura |
| Institution: | Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan |
| Abstract: | In contrast with BLM(or TALM)-Cu(II) complex system, Cu(I)-O2 system of BLM(or TALM) as well as the corresponding Fe(II) system evidently produces reactive oxygen radicals as detected by ESR spin trapping. The sulfhydryl compound strongly prevented the generation of hydroxyl radical in BLM(or TALM)-Cu(I)-O2 system. TALM forms metal complexes similar to BLM. The action mechanism of BLM and TALM has been proposed to be substantially same. |
| Keywords: | BLM bleomycin TALM tallysomycin ESR electron spin resonance BPN N-tert-butyl-α-phenylnitrone DMPO 5 5-dimethyl-l-pyroline-N-oxide DNA deoxyribonucleic acid DTT dithiothreitol |
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