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Stereoselective synthesis of 3′-C-methylene- and 2′-methyl-3′-C-methylene-3′-deoxythymidine |
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| Authors: | Elena Riehokainen Igor E Mikerin Nickolai N Slobodyan Marat B Tulebaev and Sergey E Severin |
| Institution: | a Hytest Ltd., Eurocity, Tykistokatu 2B, Turku 20520, Finland b Moscow Institute of Medical Ecology, Simferopolsky Boulevard 8, Moscow 113149, Russia |
| Abstract: | Stereoselective synthesis of 3′-C-methylene- and 2′-methyl-3′-C-methylene-3′-deoxythymidine is described, the key reaction being the formation of 3-C-methylene function by catalytic isomerization of a chiral epoxyalcohol, prepared from commercially available 3-methyl-2-butenal and 3-methyl-2-pentenal. |
| Keywords: | Dideoxynucleoside Asymmetric epoxidation 3′-Substituted thymidine |
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